Establishment of epithelial cell apical/basal polarity

Across TCGA cell cohorts, RNA activity of the Establishment of epithelial cell apical/basal polarity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4, FAM53B, and MNX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF4 grouped by Establishment of epithelial cell apical/basal polarity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TAF4 →	-0.608	-1.835	.002	<.001	3	5
URINARY_TRACT	FAM53B →	-1.545	-1.603	<.001	<.001	3	4
LARGE_INTESTINE	MNX1 →	-1.260	-1.163	.001	.001	3	4
LUNG_NSCLC_LUAD	CACNA1D →	-1.380	-1.125	.009	.001	3	4
STOMACH	ADAMTS16 →	+1.593	+1.540	.001	<.001	3	4
BONE	YY1 →	-1.027	-0.426	.007	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF4 by Establishment of epithelial cell apical/basal polarity activity — LUNG_SCLC

Explore this box plot interactively →