"Regulation of circadian sleep/wake cycle, non-REM sleep"

Across TCGA patient cohorts, RNA activity of the "Regulation of circadian sleep/wake cycle, non-REM sleep" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S290, TLN1, and DNPH1_S128, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of circadian sleep/wake cycle, non-REM sleep" activity versus VCL_S290 in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCL_S290 →	-0.974	-0.110	<.001	<.001	3	8
COAD	TLN1 →	-0.309	-0.065	<.001	<.001	3	8
PDAC	DNPH1_S128 →	-1.134	-0.112	<.001	<.001	3	8
PDAC	RCSD1_S179 →	-0.579	-0.056	<.001	<.001	3	7
COAD	RSU1 →	-0.348	-0.062	<.001	<.001	3	7
PDAC	CAVIN1 →	-0.710	-0.101	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045188 vs VCL_S290 — OV

Explore this scatter interactively →