"Regulation of circadian sleep/wake cycle, non-REM sleep"

Across TCGA pan-cancer cohorts, RNA activity of the "Regulation of circadian sleep/wake cycle, non-REM sleep" pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher "Regulation of circadian sleep/wake cycle, non-REM sleep" pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and LAML, show the opposite pattern, with higher activity associated with better survival.

KIRP, LUSC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.585	0.877	<.001	103	view →
LUSC	OS	Tertile	All	0.836	0.715	.003	51	view →
MESO	OS	Median	All	0.431	0.650	.001	38	view →
ESCA	OS	Tertile	III,IV	0.405	0.767	.007	32	view →
SARC	OS	Median	All	0.769	0.898	.001	26	view →
SKCM	OS	Median	IV	0.215	0.867	<.001	24	view →
COAD	DFS	Median	II,III,IV	0.403	0.627	.007	21	view →
HNSC	DFS	Tertile	III,IV	0.549	0.720	.006	19	view →
LIHC	DFS	Quartile	II,III,IV	0.213	0.437	.015	15	view →
LGG	OS	Median	All	0.846	0.933	<.001	13	view →
LAML	DFS	Quartile	All	0.506	0.269	.015	12	view →
STAD	DFS	Median	All	0.493	0.253	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0045188–KIRP (OS)

Open the KIRP breakdown →