"Regulation of circadian sleep/wake cycle, non-REM sleep"

Across TCGA patient cohorts, RNA activity of the "Regulation of circadian sleep/wake cycle, non-REM sleep" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNC, TMEM45A, and AKR7L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of circadian sleep/wake cycle, non-REM sleep" activity versus TNC in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNC →	-0.867	-0.433	.004	.001	3	4
PDAC	TMEM45A →	-0.770	-0.404	.004	.004	3	4
LSCC	AKR7L →	+0.275	+0.475	.001	.003	3	3
PDAC	CASP9 →	+0.275	+0.425	.002	.001	3	3
PDAC	SLC2A5 →	-0.692	-0.420	.001	.003	3	3
PDAC	SFXN4 →	+0.291	+0.376	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045188 vs TNC — LSCC

Explore this scatter interactively →