"Regulation of circadian sleep/wake cycle, non-REM sleep"

Across TCGA cell cohorts, RNA activity of the "Regulation of circadian sleep/wake cycle, non-REM sleep" pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTNR1B, KCNA2, and GHRL, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTNR1B grouped by "Regulation of circadian sleep/wake cycle, non-REM sleep"-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTNR1B →	-0.436	-1.374	.002	.008	3	12
BONE	KCNA2 →	-0.415	-1.302	.001	.003	3	11
BREAST	GHRL →	-0.241	-1.066	<.001	.002	3	7
BLOOD_Leukemia	ADORA1 →	-0.210	-0.904	.002	.004	3	7
CNS	PARP1 →	-0.225	-1.059	.001	.002	3	6
OVARY	PDE6D →	-0.156	-0.938	.007	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTNR1B by "Regulation of circadian sleep/wake cycle, non-REM sleep" activity — BLOOD_Myeloma

Explore this box plot interactively →