Apical protein localization

Across TCGA patient cohorts, RNA activity of the Apical protein localization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, ARMH3, and CTPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apical protein localization activity versus RPL5 in BRCA (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.237	-0.068	<.001	<.001	3	6
CCRCC	ARMH3 →	-0.113	-0.040	<.001	<.001	3	5
BRCA	CTPS2 →	+0.256	+0.035	<.001	.002	3	5
LSCC	PAFAH1B3 →	+0.376	+0.068	.002	<.001	3	5
BRCA	RPL23A →	-0.220	-0.043	<.001	.001	3	5
OV	C1R →	+0.444	+0.037	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045176 vs RPL5 — BRCA

Explore this scatter interactively →