Cell fate commitment

Across TCGA patient cohorts, RNA activity of the Cell fate commitment pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVA, DOCK1, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate commitment activity versus PARVA in BRCA (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PARVA →	+0.518	+0.026	<.001	<.001	3	9
UCEC	DOCK1 →	+0.426	+0.052	<.001	.001	3	9
UCEC	RSU1 →	+0.607	+0.046	<.001	<.001	3	8
OV	TNS2_S102 →	+0.967	+0.022	<.001	<.001	3	8
PDAC	TOP2A_S1213 →	-0.566	-0.024	.005	.002	3	8
BRCA	CAVIN1 →	+0.678	+0.019	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045165 vs PARVA — BRCA

Explore this scatter interactively →