Clustering of voltage-gated sodium channels

Across TCGA patient cohorts, RNA activity of the Clustering of voltage-gated sodium channels pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRCAM, FHL1, and PCTP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clustering of voltage-gated sodium channels activity versus NRCAM in LSCC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRCAM →	+0.816	+0.098	<.001	<.001	3	6
BRCA	FHL1 →	-0.694	-0.053	.001	.007	3	5
UCEC	PCTP →	-0.449	-0.125	<.001	.001	3	5
GBM	SERPING1 →	-0.485	-0.056	.001	.007	3	4
OV	CABLES1_S109 →	-0.936	-0.083	.007	.001	3	4
UCEC	HDGFL2_S454 →	-0.453	-0.122	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045162 vs NRCAM — LSCC

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