Clustering of voltage-gated sodium channels

Across TCGA cell cohorts, RNA activity of the Clustering of voltage-gated sodium channels pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEX14, TMEM45A, and PTPRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEX14 grouped by Clustering of voltage-gated sodium channels-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TEX14 →	+0.389	+1.067	<.001	.009	3	4
OESOPHAGUS	TMEM45A →	+1.853	+1.625	.002	<.001	3	4
BLOOD_Lymphoma	PTPRB →	-1.257	-1.983	.007	<.001	3	4
CNS	SGPL1 →	-0.626	-0.942	.002	.006	3	4
LUNG_NSCLC_LUAD	FBXO21 →	-0.470	-0.753	.006	.007	3	4
KIDNEY	SLC4A5 →	+0.490	+1.221	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEX14 by Clustering of voltage-gated sodium channels activity — OESOPHAGUS

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