Homologous chromosome segregation

Across TCGA patient cohorts, RNA activity of the Homologous chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, BLM, and VRK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homologous chromosome segregation activity versus NCAPH in GBM (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCAPH →	+0.692	+0.512	<.001	.003	3	6
LSCC	BLM →	+0.619	+0.596	<.001	<.001	3	6
LSCC	VRK1 →	+0.618	+0.710	<.001	.001	3	5
LSCC	RAD51AP1 →	+0.632	+0.677	<.001	<.001	3	5
UCEC	LMNB1 →	+0.711	+0.309	.001	.001	3	5
UCEC	SGO1 →	+0.582	+0.309	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045143 vs NCAPH — GBM

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