Meiotic telomere clustering

Across TCGA patient cohorts, RNA activity of the Meiotic telomere clustering pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDX, ATM, and CEP295, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic telomere clustering activity versus RDX in UVM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	RDX →	+2.091	+0.094	<.001	<.001	3	33
UVM	ATM →	+1.790	+0.106	<.001	<.001	3	33
UVM	CEP295 →	+1.107	+0.101	<.001	<.001	3	33
UVM	CUL5 →	+1.559	+0.102	<.001	<.001	3	33
UVM	VCPIP1 →	+1.640	+0.093	<.001	<.001	3	33
UVM	ATRX →	+1.299	+0.098	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045141 vs RDX — UVM

Explore this scatter interactively →