Meiotic telomere clustering

Across TCGA pan-cancer cohorts, RNA activity of the Meiotic telomere clustering pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Meiotic telomere clustering pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and UCS, show the opposite pattern, with higher activity associated with better survival.

UVM, SCLC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.226	0.664	<.001	112	view →
SCLC	OS	Median	All	0.834	0.562	<.001	102	view →
HNSC	OS	Quartile	III,IV	0.554	0.815	.001	45	view →
UCS	OS	Median	II,III,IV	0.779	0.455	.008	42	view →
STAD	DFS	Tertile	IV	0.263	0.798	.007	30	view →
BLCA	DFS	Quartile	II,III,IV	0.255	0.456	.004	24	view →
KIRC	DFS	Quartile	All	0.890	0.686	.002	20	view →
ACC	OS	Tertile	III,IV	0.589	0.176	.010	17	view →
LGG	OS	Median	All	0.923	0.853	.009	13	view →
BRCA	OS	Quartile	IV	0.930	0.276	.002	12	view →
COAD	DFS	Median	III,IV	0.593	0.720	.024	9	view →
DLBC	DFS	Quartile	III,IV	0.079	0.984	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0045141–UVM (DFS)

Open the UVM breakdown →