Meiotic telomere clustering

Across TCGA patient cohorts, RNA activity of the Meiotic telomere clustering pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAP1, TAPBP, and MAP1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic telomere clustering activity versus TAP1 in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TAP1 →	-0.530	-0.057	<.001	<.001	3	6
PDAC	TAPBP →	-0.626	-0.054	<.001	<.001	3	6
LSCC	MAP1B →	+0.581	+0.045	.001	<.001	3	6
LSCC	CRMP1 →	+0.509	+0.043	<.001	<.001	3	6
PDAC	TAP2 →	-0.759	-0.064	<.001	<.001	3	5
LUAD	DIDO1_S523 →	+0.496	+0.052	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045141 vs TAP1 — LSCC

Explore this scatter interactively →