Meiotic telomere clustering

Across TCGA patient cohorts, RNA activity of the Meiotic telomere clustering pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT16, SNORD105B, and ZNF526, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic telomere clustering activity versus SYT16 in UCEC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYT16 →	+0.463	+0.616	.005	.002	3	3
UCEC	SNORD105B →	+0.995	+0.569	<.001	.006	3	3
BRCA	ZNF526 →	+0.221	+0.467	.008	.004	3	3
BRCA	MAL →	+0.483	+0.760	<.001	<.001	3	3
PDAC	RN7SKP124 →	-0.273	-0.379	.002	.008	3	3
HNSC	SERINC5 →	-0.622	-0.429	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045141 vs SYT16 — UCEC

Explore this scatter interactively →