Meiotic telomere clustering

Across TCGA cell cohorts, RNA activity of the Meiotic telomere clustering pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STEAP1B, CSF1, and SMIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STEAP1B grouped by Meiotic telomere clustering-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STEAP1B →	+3.795	+1.784	.003	.005	2	5
LUNG_SCLC	CSF1 →	+1.659	+0.843	<.001	.002	2	4
LUNG_SCLC	SMIM1 →	+1.371	+1.002	.004	.005	3	3
SKIN	SNPH →	+0.906	+0.946	<.001	.003	3	3
LUNG_NSCLC_LUAD	MXRA7 →	+1.550	+1.320	.004	<.001	3	3
LUNG_NSCLC_LUSC	ATXN7L3B →	-0.754	-1.333	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STEAP1B by Meiotic telomere clustering activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →