Meiotic chromosome segregation

Across TCGA patient cohorts, RNA activity of the Meiotic chromosome segregation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, RFC1_S368, and RFC1_T506, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome segregation activity versus RFC1 in LUAD (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1 →	+0.329	+0.068	<.001	<.001	3	10
LUAD	RFC1_S368 →	+1.045	+0.102	<.001	<.001	3	10
LUAD	RFC1_T506 →	+1.254	+0.111	<.001	<.001	3	10
HNSC	RFC4 →	+0.529	+0.063	<.001	<.001	3	10
BRCA	RIF1 →	+0.553	+0.059	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.325	+0.102	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045132 vs RFC1 — LUAD

Explore this scatter interactively →