Meiotic chromosome segregation

Across TCGA patient cohorts, RNA activity of the Meiotic chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, SKA3, and CDCA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome segregation activity versus NUF2 in BRCA (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	+1.060	+0.831	<.001	<.001	3	8
LSCC	SKA3 →	+0.889	+0.955	<.001	<.001	3	8
UCEC	CDCA2 →	+1.033	+0.874	<.001	<.001	3	8
UCEC	ASPM →	+1.150	+0.736	<.001	<.001	3	8
UCEC	RFC3 →	+0.910	+0.963	<.001	<.001	3	7
UCEC	SPC25 →	+1.051	+0.889	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045132 vs NUF2 — BRCA

Explore this scatter interactively →