Meiotic chromosome segregation

Across TCGA cell cohorts, RNA activity of the Meiotic chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9, ACOXL, and METTL26, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome segregation activity versus TBC1D9 in OVARY (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBC1D9 →	-0.780	-0.188	.004	.002	2	6
BLOOD_Myeloma	ACOXL →	+2.098	+0.235	.002	.005	3	4
BREAST	METTL26 →	-0.703	-0.161	.001	.002	3	4
BLOOD_Leukemia	FAM120C →	+0.627	+0.153	.002	.008	3	4
LUNG_SCLC	BRAT1 →	+0.531	+0.181	<.001	.002	2	4
LUNG_SCLC	TBX2 →	-1.753	-0.194	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045132 vs TBC1D9 — OVARY

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