Cellular extravasation

Across TCGA patient cohorts, RNA activity of the Cellular extravasation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SEPTIN1, and SPECC1_S55, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular extravasation activity versus RCSD1 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.612	+0.090	<.001	<.001	3	10
GBM	SEPTIN1 →	+1.239	+0.084	<.001	<.001	3	10
LUAD	SPECC1_S55 →	+0.670	+0.079	<.001	<.001	3	10
OV	SPN →	+0.749	+0.051	<.001	<.001	3	10
OV	STK10_S514 →	+1.094	+0.058	<.001	<.001	3	10
UCEC	RCSD1_S351 →	+0.615	+0.080	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045123 vs RCSD1 — GBM

Explore this scatter interactively →