Protein neddylation

Across TCGA cell cohorts, RNA activity of the Protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL8, CSNK1G2, and NSRP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein neddylation activity versus KLHL8 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLHL8 →	+0.668	+1.360	.001	<.001	3	7
STOMACH	CSNK1G2 →	+1.368	+1.738	<.001	.003	3	6
LIVER	NSRP1 →	+0.530	+1.963	.001	<.001	3	6
PANCREAS	RBM28 →	+0.954	+1.594	.003	.002	3	6
BLOOD_Myeloma	BBS7 →	+0.915	+0.511	.001	.009	3	6
PANCREAS	DTD2 →	+0.804	+1.804	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045116 vs KLHL8 — STOMACH

Explore this scatter interactively →