Intermediate filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Intermediate filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP1, NECTIN1, and TRIM29, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament bundle assembly activity versus PKP1 in ESCA (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	PKP1 →	+3.140	+0.108	<.001	<.001	3	20
UCS	NECTIN1 →	+1.308	+0.085	<.001	<.001	3	19
ESCA	TRIM29 →	+2.417	+0.130	<.001	<.001	3	17
LGG	NEFH →	+2.430	+0.316	<.001	<.001	3	16
CHOL	KRT17 →	+4.265	+0.117	<.001	.001	3	16
ESCA	S100A2 →	+2.939	+0.123	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045110 vs PKP1 — ESCA

Explore this scatter interactively →