Intermediate filament bundle assembly

Across TCGA pan-cancer cohorts, RNA activity of the Intermediate filament bundle assembly pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and LIHC, show the opposite pattern, with lower activity in tumor tissue.

LUSC, HNSC, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUSC	Male	III,IV	+0.355	<.001	9	view →
HNSC	Male	All	+0.104	<.001	9	view →
BLCA	Male	III,IV	+0.214	.002	7	view →
COAD	Female	All	+0.133	<.001	6	view →
LUAD	Male	All	+0.101	<.001	6	view →
BRCA	Female	All	−0.049	<.001	6	view →
LIHC	Female	II,III,IV	−0.165	<.001	4	view →
KIRP	Female	All	+0.104	.003	4	view →
THCA	Male	All	+0.071	.002	4	view →
CHOL	All	All	−0.142	.002	3	view →
READ	Female	All	+0.177	.009	2	view →
PRAD	All	All	−0.035	.015	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0045110–LUSC

Open the LUSC breakdown →