Intermediate filament bundle assembly

Across TCGA patient cohorts, RNA activity of the Intermediate filament bundle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPPK1, JUP, and EIF3F_S258, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament bundle assembly activity versus EPPK1 in LUAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EPPK1 →	+0.665	+0.370	<.001	<.001	3	6
LSCC	JUP →	+0.633	+0.127	<.001	<.001	3	6
BRCA	EIF3F_S258 →	+0.694	+0.117	<.001	<.001	3	6
CCRCC	EPPK1_S2718 →	+0.730	+0.179	<.001	<.001	3	6
PDAC	HSPA12B →	-0.393	-0.109	<.001	<.001	3	6
PDAC	RBSN →	-0.187	-0.108	.001	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045110 vs EPPK1 — LUAD

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