Intermediate filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Intermediate filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP12, DTX3, and PSAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP12 grouped by Intermediate filament bundle assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARHGAP12 →	-1.510	-1.890	.001	.001	3	4
BLOOD_Leukemia	DTX3 →	-2.568	-1.213	.007	.007	3	4
BLOOD_Leukemia	PSAP →	-1.988	-1.398	.001	.005	3	4
SOFT_TISSUE	TMEM89 →	-0.155	-1.340	.006	<.001	3	3
SOFT_TISSUE	TMEM120B →	-0.685	-1.318	.009	.007	3	3
SOFT_TISSUE	SH3GLB1 →	-0.958	-1.101	.003	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP12 by Intermediate filament bundle assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →