Intermediate filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Intermediate filament bundle assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD226, MBL2, and ATP5F1D, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD226 grouped by Intermediate filament bundle assembly-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CD226 →	+0.115	+0.434	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	MBL2 →	-0.216	-0.416	.004	.004	3	3
OESOPHAGUS	ATP5F1D →	+0.298	+0.605	<.001	<.001	3	3
OVARY	RNASE10 →	+0.202	+0.404	.006	.001	3	3
LARGE_INTESTINE	HPCA →	-0.158	-0.338	.004	.002	3	3
LUNG_NSCLC_LUAD	SUMO1 →	-0.163	-0.855	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD226 by Intermediate filament bundle assembly activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →