Intermediate filament bundle assembly

Across TCGA cell cohorts, RNA activity of the Intermediate filament bundle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPPK1, RPRD1A, and USP43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intermediate filament bundle assembly activity versus EPPK1 in LARGE_INTESTINE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EPPK1 →	+1.338	+0.457	.009	.001	3	6
CNS	RPRD1A →	-0.788	-1.276	.004	.005	3	5
KIDNEY	USP43 →	+1.069	+1.366	.005	.006	3	4
KIDNEY	SNED1 →	-0.474	-1.366	.001	.006	3	4
KIDNEY	TMEM67 →	-0.776	-1.366	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	DROSHA →	-1.349	-0.432	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045110 vs EPPK1 — LARGE_INTESTINE

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