Positive regulation of viral genome replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of viral genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS7, KPNA2, and RPP30, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of viral genome replication activity versus RPS7 in COAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS7 →	+0.404	+0.344	<.001	<.001	3	8
LSCC	KPNA2 →	+0.600	+0.205	<.001	<.001	3	8
LSCC	RPP30 →	+0.291	+0.206	<.001	<.001	2	8
UCEC	SMC2 →	+0.727	+0.387	<.001	<.001	3	7
LSCC	ZC3HC1_S24 →	+0.699	+0.194	<.001	<.001	3	7
LUAD	CDYL_S216 →	+0.781	+0.290	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045070 vs RPS7 — COAD

Explore this scatter interactively →