Positive regulation of viral genome replication

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of viral genome replication pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Positive regulation of viral genome replication pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.557	0.679	<.001	132	view →
KIRP	DFS	Median	All	0.780	0.910	<.001	94	view →
UCEC	DFS	Tertile	All	0.764	0.877	.002	56	view →
MESO	OS	Tertile	All	0.278	0.549	<.001	53	view →
ACC	OS	Quartile	All	0.552	0.905	<.001	48	view →
UVM	DFS	Quartile	III,IV	0.368	0.923	.001	42	view →
KICH	DFS	Quartile	II,III,IV	0.442	1.000	.008	34	view →
LUAD	OS	Tertile	II,III,IV	0.681	0.383	.001	29	view →
LGG	DFS	Tertile	All	0.781	0.892	.001	29	view →
READ	OS	Tertile	II,III,IV	0.970	0.495	.005	18	view →
SKCM	OS	Median	IV	0.867	0.244	.006	15	view →
OV	OS	Quartile	III,IV	0.469	0.361	.028	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0045070–KIRC (DFS)

Open the KIRC breakdown →