Positive regulation of viral genome replication

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD55, NECAB3, and EMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD55 grouped by Positive regulation of viral genome replication-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CD55 →	+2.049	+0.227	.009	.003	3	5
BONE	NECAB3 →	-0.871	-0.226	.006	<.001	3	4
PANCREAS	EMP1 →	+2.285	+0.271	.003	<.001	3	4
PANCREAS	TBC1D32 →	-0.835	-0.242	.003	.003	3	4
PANCREAS	C21orf58 →	-0.624	-0.173	.004	.001	3	4
LARGE_INTESTINE	ADAMTS9 →	+1.183	+0.215	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD55 by Positive regulation of viral genome replication activity — LIVER

Explore this box plot interactively →