T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KREMEN2, STC1, and NEK8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KREMEN2 grouped by T-helper 2 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KREMEN2 →	+1.567	+0.268	<.001	.001	3	4
LUNG_SCLC	STC1 →	+3.917	+1.317	.001	.001	3	3
BREAST	NEK8 →	+0.758	+0.251	<.001	.001	3	3
CNS	C2orf92 →	+0.800	+0.833	<.001	<.001	3	3
PANCREAS	TRIM38 →	-1.091	-1.139	<.001	<.001	3	3
PANCREAS	C4A →	-0.556	-0.911	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KREMEN2 by T-helper 2 cell differentiation activity — BREAST

Explore this box plot interactively →