T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT2A, RNF214, and HINFP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 2 cell differentiation activity versus KMT2A in KIDNEY (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KMT2A →	+0.993	+0.237	<.001	<.001	3	14
LIVER	RNF214 →	+0.772	+0.230	.003	<.001	3	12
OESOPHAGUS	HINFP →	+0.789	+0.188	<.001	<.001	3	11
OVARY	VPS26B →	+1.034	+0.191	<.001	<.001	3	10
LUNG_SCLC	NFRKB →	+0.905	+0.268	<.001	<.001	3	10
OVARY	UBE4A →	+0.645	+0.173	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045064 vs KMT2A — KIDNEY

Explore this scatter interactively →