T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 2 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT1, ZDHHC2, and VIPR2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGT1 grouped by T-helper 2 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GGT1 →	+0.186	+2.249	<.001	<.001	3	1
BREAST	ZDHHC2 →	+0.520	+2.232	.006	<.001	3	1
BREAST	VIPR2 →	+0.416	+2.129	.005	<.001	3	1
BREAST	ERGIC1 →	+0.148	+2.102	.002	<.001	3	1
BREAST	OR1E2 →	+0.636	+2.211	.004	<.001	3	1
BREAST	ZNF780B →	+0.253	+2.190	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGT1 by T-helper 2 cell differentiation activity — BREAST

Explore this box plot interactively →