T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF7, PLEKHG4, and TUBB1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 2 cell differentiation activity versus KLF7 in BREAST (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLF7 →	-2.505	-2.213	.006	.005	3	2
BREAST	PLEKHG4 →	+4.250	+2.188	.002	<.001	3	2
BREAST	TUBB1 →	+0.260	+2.279	.002	.004	3	1
BREAST	CAB39L →	+2.223	+2.144	<.001	<.001	3	1
BREAST	ZNF175 →	+1.344	+2.228	.005	.006	2	2
BREAST	RPL28 →	-1.396	-2.188	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045064 vs KLF7 — BREAST

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