Transcytosis

Across TCGA patient cohorts, RNA activity of the Transcytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BZW2, CHAF1B_S410, and DHFR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcytosis activity versus BZW2 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BZW2 →	-0.368	-0.064	.002	.002	3	8
LSCC	CHAF1B_S410 →	-0.600	-0.071	.007	.002	3	6
GBM	DHFR →	-0.522	-0.047	<.001	<.001	3	6
BRCA	IARS1 →	-0.197	-0.036	.005	.009	3	6
LSCC	EIF3H_S183 →	-0.324	-0.060	<.001	<.001	3	6
GBM	NCL_S67 →	-0.706	-0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045056 vs BZW2 — LSCC

Explore this scatter interactively →