Transcytosis

Across TCGA patient cohorts, RNA activity of the Transcytosis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGR, SLC44A4, and KCNQ1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcytosis activity versus PIGR in CCRCC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PIGR →	+2.696	+0.249	<.001	<.001	3	8
CCRCC	SLC44A4 →	+1.484	+0.248	<.001	<.001	3	6
LSCC	KCNQ1 →	+0.529	+0.081	.006	.009	3	6
COAD	TNFRSF14 →	+0.392	+0.120	.002	.004	3	5
BRCA	RAB17 →	+0.765	+0.162	<.001	<.001	3	5
BRCA	TMC5 →	+1.328	+0.146	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045056 vs PIGR — CCRCC

Explore this scatter interactively →