Transcytosis

Across TCGA cell cohorts, RNA activity of the Transcytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTBS, CREB3, and SEC31A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcytosis activity versus CTBS in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTBS →	+1.105	+0.176	<.001	.002	3	6
BONE	CREB3 →	+1.785	+0.506	<.001	.002	3	6
LIVER	SEC31A →	+1.077	+0.455	.001	<.001	3	6
BLOOD_Lymphoma	TMF1 →	+0.829	+0.183	<.001	<.001	3	5
BLOOD_Leukemia	STXBP5 →	+2.671	+0.266	<.001	<.001	3	5
LIVER	SDR39U1 →	-0.607	-0.280	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045056 vs CTBS — BLOOD_Lymphoma

Explore this scatter interactively →