Protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Across TCGA patient cohorts, RNA activity of the Protein insertion into ER membrane by stop-transfer membrane-anchor sequence pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDHD1, PRMT5, and SHOC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence activity versus WDHD1 in LUAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WDHD1 →	+0.663	+0.051	<.001	<.001	3	5
CCRCC	PRMT5 →	+0.210	+0.055	<.001	<.001	3	5
OV	SHOC2 →	-0.393	-0.047	.004	.005	3	4
LUAD	SUPT16H →	+0.235	+0.050	.003	<.001	2	5
CCRCC	DCAF11 →	+0.258	+0.057	<.001	<.001	3	4
LSCC	DHX57_S127 →	+0.640	+0.057	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045050 vs WDHD1 — LUAD

Explore this scatter interactively →