Protein insertion into mitochondrial inner membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into mitochondrial inner membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRFIP1, RANBP6, and SUPT16H, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into mitochondrial inner membrane activity versus LRRFIP1 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRFIP1 →	-0.295	-0.038	<.001	.006	3	6
PDAC	RANBP6 →	+0.224	+0.029	<.001	<.001	3	6
LSCC	SUPT16H →	+0.374	+0.051	<.001	<.001	3	6
PDAC	RPL13_S140 →	-0.568	-0.036	<.001	<.001	3	5
LSCC	ITGB4_T1530 →	-1.023	-0.043	<.001	.001	3	5
CCRCC	P4HB →	-0.385	-0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045039 vs LRRFIP1 — LSCC

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