Protein insertion into mitochondrial inner membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into mitochondrial inner membrane pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, CR1, and HIC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into mitochondrial inner membrane activity versus ITGB1 in OV (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGB1 →	-0.685	-0.129	<.001	.003	3	6
COAD	CR1 →	-0.460	-0.137	<.001	.001	3	6
LSCC	HIC1 →	-0.414	-0.121	.004	.009	3	6
COAD	CSF2RB →	-0.566	-0.127	.007	.007	3	5
BRCA	CNTRL →	-0.516	-0.210	<.001	<.001	3	5
LSCC	GLB1L →	-0.605	-0.176	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045039 vs ITGB1 — OV

Explore this scatter interactively →