Glycerolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycerolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLHC1, RNF43, and SLAIN2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid biosynthetic process activity versus CLHC1 in OV (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLHC1 →	+0.680	+0.347	.003	<.001	3	2
BRCA	RNF43 →	+1.618	+0.208	.008	.009	3	1
BRCA	SLAIN2 →	+0.733	+0.191	.002	.002	3	1
BRCA	FBXW7 →	+0.679	+0.184	.007	.006	2	2
BRCA	CAT →	+0.654	+0.188	.003	.005	3	1
BRCA	PAIP2B →	+1.381	+0.199	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045017 vs CLHC1 — OV

Explore this scatter interactively →