Glycerolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycerolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A1, CPA4, and PLCB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC1A1 grouped by Glycerolipid biosynthetic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC1A1 →	+1.588	+1.218	.003	<.001	3	4
LUNG_NSCLC_LUAD	CPA4 →	-2.148	-0.665	.005	.006	3	4
LUNG_NSCLC_LUAD	PLCB1 →	+1.407	+0.870	.001	<.001	3	4
LUNG_NSCLC_LUAD	DENND1C →	+1.324	+0.697	<.001	<.001	3	4
BREAST	EVI5L →	-0.850	-0.671	.001	.008	3	4
LUNG_NSCLC_LUSC	PLP2 →	-1.519	-1.271	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC1A1 by Glycerolipid biosynthetic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →