Glycerolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycerolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT2, VPS9D1, and MLYCD, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid biosynthetic process activity versus STAT2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	STAT2 →	+1.237	+0.037	.009	.006	3	17
UPPER_AERODIGESTIVE_TRACT	VPS9D1 →	+0.889	+0.040	.003	.002	3	17
BLOOD_Myeloma	MLYCD →	+0.717	+0.036	.003	<.001	3	16
BREAST	VMAC →	+1.211	+0.037	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	TRAPPC10 →	+1.096	+0.045	<.001	<.001	3	16
STOMACH	MTMR3 →	+0.832	+0.045	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045017 vs STAT2 — UPPER_AERODIGESTIVE_TRACT

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