Glycerolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glycerolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG10, EPHB3, and ERC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerolipid biosynthetic process activity versus ATG10 in BONE (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ATG10 →	-0.878	-1.305	.006	.009	3	4
LUNG_SCLC	EPHB3 →	+2.162	+0.989	.001	.004	3	4
BONE	ERC1 →	-1.292	-1.235	<.001	.001	3	4
BREAST	AURKB →	-1.138	-1.236	.005	.002	3	3
OVARY	HMGN4 →	-1.039	-1.483	<.001	<.001	3	3
LUNG_NSCLC_LUSC	SCN9A →	-1.545	-1.686	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045017 vs ATG10 — BONE

Explore this scatter interactively →