Actin nucleation

Across TCGA patient cohorts, RNA activity of the Actin nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL30, PSMD3, and RPL10A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin nucleation activity versus RPL30 in CCRCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL30 →	-0.213	-0.040	.002	<.001	3	8
GBM	PSMD3 →	-0.155	-0.041	.005	.002	3	8
GBM	RPL10A →	-0.205	-0.041	<.001	<.001	3	8
BRCA	FRZB →	+0.752	+0.027	<.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.692	+0.030	<.001	<.001	3	7
OV	RPL18A →	-0.300	-0.037	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045010 vs RPL30 — CCRCC

Explore this scatter interactively →