Actin nucleation

Across TCGA cell cohorts, RNA activity of the Actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC2, MOB3A, and ARPC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin nucleation activity versus ARPC2 in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARPC2 →	+0.857	+0.413	<.001	.001	3	9
OVARY	MOB3A →	+0.871	+0.364	.005	.004	2	6
BLOOD_Leukemia	ARPC4 →	+0.887	+0.219	.006	.005	3	5
STOMACH	CTDSP1 →	+1.264	+0.441	<.001	<.001	3	5
BLOOD_Myeloma	GLIPR1 →	+2.143	+0.367	<.001	<.001	3	5
BLOOD_Leukemia	FAM43A →	+2.331	+0.270	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045010 vs ARPC2 — STOMACH

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