DNA deamination

Across TCGA patient cohorts, RNA activity of the DNA deamination pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOBEC3G, TRIM21, and FMNL1_S1031, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA deamination activity versus APOBEC3G in COAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	APOBEC3G →	+0.765	+0.266	<.001	<.001	3	6
GBM	TRIM21 →	+0.487	+0.167	<.001	<.001	3	4
OV	FMNL1_S1031 →	+1.002	+0.448	<.001	<.001	3	4
OV	MICAL1_T475 →	+1.062	+0.302	<.001	<.001	3	4
OV	SRRT_S493 →	+0.522	+0.199	<.001	<.001	3	3
PDAC	YEATS2_S447 →	+0.479	+0.194	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045006 vs APOBEC3G — COAD

Explore this scatter interactively →