Double-strand break repair via synthesis-dependent strand annealing

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via synthesis-dependent strand annealing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH10, CORO2B, and HMGB1P5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via synthesis-dependent strand annealing activity versus RDH10 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RDH10 →	+0.888	+0.175	<.001	<.001	3	3
OV	CORO2B →	-2.487	-0.172	.003	.009	3	3
UCEC	HMGB1P5 →	+0.566	+0.286	.003	<.001	3	3
UCEC	VENTX →	-0.376	-0.283	<.001	.002	3	3
UCEC	GPR180 →	+0.443	+0.309	.001	<.001	3	3
UCEC	IRAG1-AS1 →	-0.626	-0.264	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045003 vs RDH10 — LSCC

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