Double-strand break repair via single-strand annealing

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via single-strand annealing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP8, RASGRF2, and RPS4XP18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via single-strand annealing activity versus RBBP8 in BRCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBBP8 →	+0.945	+0.347	<.001	<.001	3	6
BRCA	RASGRF2 →	-0.616	-0.255	<.001	.005	3	4
LSCC	RPS4XP18 →	+0.295	+0.238	.009	.008	3	4
LSCC	RN7SL745P →	+0.720	+0.277	<.001	<.001	3	4
BRCA	LINC00683 →	+0.275	+0.275	.001	.002	3	4
PDAC	SH3D19 →	-0.305	-0.248	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045002 vs RBBP8 — BRCA

Explore this scatter interactively →