Estrous cycle

Across TCGA cell cohorts, RNA activity of the Estrous cycle pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PATZ1, TCFL5, and ZNF92, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrous cycle activity versus PATZ1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PATZ1 →	+1.448	+0.276	.002	.005	3	6
BLOOD_Leukemia	TCFL5 →	+0.962	+0.103	.005	.005	3	5
BLOOD_Lymphoma	ZNF92 →	+1.143	+0.149	.001	.001	3	5
BREAST	TMEM254 →	+0.929	+0.145	.003	<.001	3	5
BLOOD_Lymphoma	PARVB →	-2.991	-0.151	.007	.005	2	6
BLOOD_Lymphoma	FOSL1 →	-1.721	-0.147	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044849 vs PATZ1 — UPPER_AERODIGESTIVE_TRACT

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