Cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIAS3, ATP5F1B, and MRPS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIAS3 grouped by Cell cycle G1/S phase transition-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PIAS3 →	+1.239	+0.226	.002	.004	3	5
LUNG_NSCLC_LUAD	ATP5F1B →	-0.678	-0.150	.001	.002	3	4
LARGE_INTESTINE	MRPS2 →	-0.571	-0.201	.007	.002	3	4
SOFT_TISSUE	TTLL3 →	+1.818	+0.215	.003	.008	3	4
LARGE_INTESTINE	SARNP →	-0.474	-0.187	.007	.009	3	4
BLOOD_Myeloma	EPB41 →	-1.032	-0.266	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIAS3 by Cell cycle G1/S phase transition activity — BLOOD_Myeloma

Explore this box plot interactively →